Literature summary for 1.14.13.25 extracted from

Wang, W.; Iacob, R.E.; Luoh, R.P.; Engen, J.R.; Lippard, S.J.
Electron transfer control in soluble methane monooxygenase (2014), J. Am. Chem. Soc., 136, 9754-9762 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Methylococcus capsulatus	5737	-

Organism

Organism	UniProt	Comment	Textmining
Methylococcus capsulatus	P22869 and P18798 and P11987 and P18797 and P22868 and P22867	P22869 (MmoX), P18798 (MmoY), P11987 (MmoZ), P18797 (MmoB), P22868 (MmoC), P22867 (MmoD). The soluble methane monooxygenase (sMMO) consists of four components A/MMOH (composed of alpha/MmoX, beta/MmoY and gamma/MmoZ), B/MMOB (MmoB), C/MMOR (MmoC) and D/MMOD (MmoD)	-
Methylococcus capsulatus Bath.	P22869 and P18798 and P11987 and P18797 and P22868 and P22867	P22869 (MmoX), P18798 (MmoY), P11987 (MmoZ), P18797 (MmoB), P22868 (MmoC), P22867 (MmoD). The soluble methane monooxygenase (sMMO) consists of four components A/MMOH (composed of alpha/MmoX, beta/MmoY and gamma/MmoZ), B/MMOB (MmoB), C/MMOR (MmoC) and D/MMOD (MmoD)	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	multicomponent monooxygenase. The ferredoxin domain of the reductase binds to the canyon region of the hydroxylase, previously determined to be the regulatory protein binding site as well. The latter thus inhibits reductase binding to the hydroxylase and, consequently, intermolecular electron transfer from the reductase to the hydroxylase diiron active site. The binding competition between the regulatory protein and the reductase may serve as a control mechanism for regulating electron transfer, and other BMM enzymes are likely to adopt the same mechanism	Methylococcus capsulatus	?	-	?
additional information	multicomponent monooxygenase. The ferredoxin domain of the reductase binds to the canyon region of the hydroxylase, previously determined to be the regulatory protein binding site as well. The latter thus inhibits reductase binding to the hydroxylase and, consequently, intermolecular electron transfer from the reductase to the hydroxylase diiron active site. The binding competition between the regulatory protein and the reductase may serve as a control mechanism for regulating electron transfer, and other BMM enzymes are likely to adopt the same mechanism	Methylococcus capsulatus Bath.	?	-	?

Synonyms

Synonyms	Comment	Organism
sMMO	-	Methylococcus capsulatus
soluble methane monooxygenase	-	Methylococcus capsulatus

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Release 2023.1 (January 2023)